The Clotting Factors
Posted: Saturday, May 2nd, 2020 | Updated: Monday, February 7th, 2022
Posted: Saturday, May 2nd, 2020 | Updated: Monday, February 7th, 2022
Clotting Factor Names
Factor I: Fibrinogen Factor II: Prothrombin Factor III: Tissue Factor Factor IV: Calcium Ions Factor V: Proaccelerin Factor VII: Proconvertin Factor VIII: Antihemophilic Factor A Factor IX: Plasma Thromboplastin Component Factor X: Stuart Factor Factor XI: Plasma Thromboplastin Antecedent Factor XII: Hageman Factor Factor XIII: Fibrin Stabilizing Factor |
Vitamin K Dependent Factors Factor II Prothrombin Factor VII Proconvertin Factor IX Plasma Thromboplastin Component Factor X Stuart Factor Hemophilia Factors Deficiency in Factor VIII = Hemophilia A Deficiency in Factor IX = Hemophilia B Deficiency in Factor XI = Hemophilia C Labile/Unstable Clotting Factors
Factor V (Proaccelerin) Factor VIII (Hemophilia A) These factors are in FFP and not Frozen/Stored Plasma |
Intrinsic Pathway (aPTT) 1. Factor XII Hageman Factor 2. Factor XI Plasma Thromboplastin Antecedent 3. Factor IX Plasma Thromboplastin Component 4. Factor VIII Antihemophilic Factor A 5. See "The Common Pathway" The intrinsic pathway activates when Vessels get injured or damaged exposing underlying tissues |
Extrinsic Pathway (PT) 1. Factor III: Tissue Factor 2. Factor VII: Proconvertin 3. See "The Common Pathway" The extrinsic pathway activates when Tissue cell trauma exposes blood |
The Common Pathway 1. Factor X: Stuart Factor 2. Factor V: Proaccelerin 3. Factor II: Prothrombin 4. Factor I: Fibrinogen |
Calcium Ions (Factor IV) are required for the coagulation factors to bind with phospholipids and are needed for essentially all stages of the coagulation process
Other Notes:
1. Vitamin K rodenticide toxicity will most notably prolong the extrinsic pathway (PT) prior to aPTT; specifically Factor VII
2. FFP may be used for vWD, but cryoprecipitate is preferred
3. Cryoprecipitate contains more concentrated amounts of Factor I (Fibrinogen), Factor VIII (Hemophilia A), Factor XIII (Fibrin Stabilizing Factor), and vWF
4. Factor IX is also known as Christmas Factor
5. Factor VII is also known as Stable Factor. Factor V is also known as Labile Factor
1. Vitamin K rodenticide toxicity will most notably prolong the extrinsic pathway (PT) prior to aPTT; specifically Factor VII
2. FFP may be used for vWD, but cryoprecipitate is preferred
3. Cryoprecipitate contains more concentrated amounts of Factor I (Fibrinogen), Factor VIII (Hemophilia A), Factor XIII (Fibrin Stabilizing Factor), and vWF
4. Factor IX is also known as Christmas Factor
5. Factor VII is also known as Stable Factor. Factor V is also known as Labile Factor
Sources:
Ford, Richard B., and Elisa M. Mazzaferro. Kirk and Bistner's Handbook of Veterinary Procedures and Emergency Treatment. 8th ed., Saunders Elsevier, 2006.
Marieb, Elaine N., and Katja Hoehn. Human Anatomy & Physiology. 8th ed., Benjamin Cummings, 2010.
Poli, Gerardo. MiniVet Guide: Companion Animal Medicine. InHouse Publishing, 2016.
Ford, Richard B., and Elisa M. Mazzaferro. Kirk and Bistner's Handbook of Veterinary Procedures and Emergency Treatment. 8th ed., Saunders Elsevier, 2006.
Marieb, Elaine N., and Katja Hoehn. Human Anatomy & Physiology. 8th ed., Benjamin Cummings, 2010.
Poli, Gerardo. MiniVet Guide: Companion Animal Medicine. InHouse Publishing, 2016.