Propofol CRI
Posted: Sunday, October 10th, 2021 | Updated: Sunday, October 10th, 2021
Posted: Sunday, October 10th, 2021 | Updated: Sunday, October 10th, 2021
Doctor's Order:
Start a Propofol CRI at 150 mcg/kg/min. Draw up 4 hours worth of Propofol
Patient Weight:
15 kg
Propofol Concentration:
10 mg/ml
Convert the Propofol from mg to mcg:
(10 mg/ml) x (1,000 mcg/mg) = 10,000 mcg/ml concentration of Propofol
Complete the Math:
(150 mcg/kg/min) x (15 kg) = 2250 mcg/min of Propofol
(2,250 mcg/min) x (60 min/hr) = 135,000 mcg/hr Propofol
(135,000 mcg/hr) / (10,000 mcg/ml) = 13.5 ml/hr of Propofol
(13.5 ml/hr) x (4 hr) = 54 ml Propofol
The Result:
You will need 54 ml of Propofol to run the CRI at 150 mcg/kg/min or 13.5 ml/hr for 4 hours
*Note Per Plumb's as of 10/10/21: "Drugs known to be incompatible with propofol at Y-site administration include: amphotericin B, atracurium, calcium chloride, ceftazidime, diazepam, gentamicin, lidocaine (concentration dependent), methylprednisolone sodium succinate, metoclopramide, tobramycin, and verapamil."
Start a Propofol CRI at 150 mcg/kg/min. Draw up 4 hours worth of Propofol
Patient Weight:
15 kg
Propofol Concentration:
10 mg/ml
Convert the Propofol from mg to mcg:
(10 mg/ml) x (1,000 mcg/mg) = 10,000 mcg/ml concentration of Propofol
Complete the Math:
(150 mcg/kg/min) x (15 kg) = 2250 mcg/min of Propofol
(2,250 mcg/min) x (60 min/hr) = 135,000 mcg/hr Propofol
(135,000 mcg/hr) / (10,000 mcg/ml) = 13.5 ml/hr of Propofol
(13.5 ml/hr) x (4 hr) = 54 ml Propofol
The Result:
You will need 54 ml of Propofol to run the CRI at 150 mcg/kg/min or 13.5 ml/hr for 4 hours
*Note Per Plumb's as of 10/10/21: "Drugs known to be incompatible with propofol at Y-site administration include: amphotericin B, atracurium, calcium chloride, ceftazidime, diazepam, gentamicin, lidocaine (concentration dependent), methylprednisolone sodium succinate, metoclopramide, tobramycin, and verapamil."
Sources:
Plumb's. Vers. 2021.9.3. Educational Concepts, LLC. Google Play, https://play.google.com/store/apps/details?id=com.plumbs.app.
Plumb's. Vers. 2021.9.3. Educational Concepts, LLC. Google Play, https://play.google.com/store/apps/details?id=com.plumbs.app.