Magnesium Sulfate CRI
Posted: Monday, January 16th, 2023 | Updated: Monday, January 16th, 2023
Posted: Monday, January 16th, 2023 | Updated: Monday, January 16th, 2023
Doctor's Order:
Start a Magnesium Sulfate CRI at 0.02 meq/kg/hr
Patient Weight:
21 kg
Magnesium Sulfate 50% or 500 mg/ml Concentration:
4.06 meq/ml
Standard Dilution Protocol (Varies By Hospital):
Dilute Magnesium Sulfate with 0.9% NaCl where 0.01 meq/kg/hr = 1 ml/hr and create a 12 hour CRI at that rate. Make sure the final diluted concentration of Magnesium Sulfate is below 20% or 200 mg/ml. If it's not, dilute it further
Complete the Math:
(0.01 meq/kg/hr) x (21 kg) = 0.21 meq/hr Magnesium Sulfate
(0.21 meq/hr) / (4.06 meq/ml) = 0.05172 ml/hr Magnesium Sulfate
(0.05 ml/hr) x (12 hr) = 0.62 ml Magnesium Sulfate
(12 ml Total Fluid Volume) - (0.62 ml Magnesium Sulfate) = 11.38 ml 0.9% NaCl
Making Sure the Final Concentration is Under 20%:
(0.62 ml Magnesium) x (500 mg/ml) = 310 mg Magnesium Sulfate
(310 mg) / (12 ml Total Fluid Volume) = 25.83 mg/ml or 2.583% Magnesium Concentration
The Result:
You will need 0.62 ml of Magnesium Sulfate 50% to mix with 11.38 ml of 0.9% NaCl. This will result in 0.01 meq/kg/hr = 1 ml/hr. To run the Magnesium Sulfate CRI at 0.02 meq/kg/hr, increase the fluid rate of your CRI to 2 ml/hr
*Note Per Plumb's as of 01/16/23: "Magnesium sulfate is reportedly physically incompatible with alkali hydroxides, alkali carbonates, salicylates, and many metals. It is incompatible with 10% lipids, dobutamine HCL, polymyxin B sulfate, procaine HCL, and sodium bicarbonate solutions."
Start a Magnesium Sulfate CRI at 0.02 meq/kg/hr
Patient Weight:
21 kg
Magnesium Sulfate 50% or 500 mg/ml Concentration:
4.06 meq/ml
Standard Dilution Protocol (Varies By Hospital):
Dilute Magnesium Sulfate with 0.9% NaCl where 0.01 meq/kg/hr = 1 ml/hr and create a 12 hour CRI at that rate. Make sure the final diluted concentration of Magnesium Sulfate is below 20% or 200 mg/ml. If it's not, dilute it further
Complete the Math:
(0.01 meq/kg/hr) x (21 kg) = 0.21 meq/hr Magnesium Sulfate
(0.21 meq/hr) / (4.06 meq/ml) = 0.05172 ml/hr Magnesium Sulfate
(0.05 ml/hr) x (12 hr) = 0.62 ml Magnesium Sulfate
(12 ml Total Fluid Volume) - (0.62 ml Magnesium Sulfate) = 11.38 ml 0.9% NaCl
Making Sure the Final Concentration is Under 20%:
(0.62 ml Magnesium) x (500 mg/ml) = 310 mg Magnesium Sulfate
(310 mg) / (12 ml Total Fluid Volume) = 25.83 mg/ml or 2.583% Magnesium Concentration
The Result:
You will need 0.62 ml of Magnesium Sulfate 50% to mix with 11.38 ml of 0.9% NaCl. This will result in 0.01 meq/kg/hr = 1 ml/hr. To run the Magnesium Sulfate CRI at 0.02 meq/kg/hr, increase the fluid rate of your CRI to 2 ml/hr
*Note Per Plumb's as of 01/16/23: "Magnesium sulfate is reportedly physically incompatible with alkali hydroxides, alkali carbonates, salicylates, and many metals. It is incompatible with 10% lipids, dobutamine HCL, polymyxin B sulfate, procaine HCL, and sodium bicarbonate solutions."
Sources:
Plumb's Veterinary Drugs App accessed from Instinct on 01/16/23.
Plumb's Veterinary Drugs App accessed from Instinct on 01/16/23.