Dexmedetomidine CRI
Posted: Sunday, October 10th, 2021 | Updated: Sunday, October 10th, 2021
Posted: Sunday, October 10th, 2021 | Updated: Sunday, October 10th, 2021
Doctor's Order:
Start a Dexmedetomidine CRI at 2 mcg/kg/hr
Patient Weight:
30 kg
Standard Dilution Protocol (Varies By Hospital):
Dilute Dexmedetomidine with 0.9% NaCl where 1 mcg/kg/hr = 1 ml/hr and create a 10 hour CRI at that rate
Dexmedetomidine Concentration:
0.5 mg/ml
Convert the Dexmedetomidine from mg to mcg:
(0.5 mg/ml) x (1,000 mcg/mg) = 500 mcg/ml concentration of Dexmedetomidine
Complete the Math:
(1 mcg/kg/hr) x (30 kg) = 30 mcg/hr of Dexmedetomidine
(30 mcg/hr) / (500 mcg/ml) = 0.06 ml/hr of Dexmedetomidine
(0.06 ml/hr) x (10 hr) = 0.6 ml Dexmedetomidine
(10 ml Total Fluid Volume) - (0.6 ml Dexmedetomidine) = 9.4 ml 0.9 % NaCl
The Result:
You will need 0.6 ml of Dexmedetomidine to mix with 9.4 ml of 0.9% NaCl. This will result in 1 mcg/kg/hr = 1 ml/hr. To run the Dexmedetomidine CRI at 2 mcg/kg/hr, increase the fluid rate of your CRI to 2 ml/hr
*Note Per Plumb's as of 10/10/21: "Dexmedetomidine is incompatible with amphotericin B, diazepam, pantoprazole, and blood or plasma products."
Start a Dexmedetomidine CRI at 2 mcg/kg/hr
Patient Weight:
30 kg
Standard Dilution Protocol (Varies By Hospital):
Dilute Dexmedetomidine with 0.9% NaCl where 1 mcg/kg/hr = 1 ml/hr and create a 10 hour CRI at that rate
Dexmedetomidine Concentration:
0.5 mg/ml
Convert the Dexmedetomidine from mg to mcg:
(0.5 mg/ml) x (1,000 mcg/mg) = 500 mcg/ml concentration of Dexmedetomidine
Complete the Math:
(1 mcg/kg/hr) x (30 kg) = 30 mcg/hr of Dexmedetomidine
(30 mcg/hr) / (500 mcg/ml) = 0.06 ml/hr of Dexmedetomidine
(0.06 ml/hr) x (10 hr) = 0.6 ml Dexmedetomidine
(10 ml Total Fluid Volume) - (0.6 ml Dexmedetomidine) = 9.4 ml 0.9 % NaCl
The Result:
You will need 0.6 ml of Dexmedetomidine to mix with 9.4 ml of 0.9% NaCl. This will result in 1 mcg/kg/hr = 1 ml/hr. To run the Dexmedetomidine CRI at 2 mcg/kg/hr, increase the fluid rate of your CRI to 2 ml/hr
*Note Per Plumb's as of 10/10/21: "Dexmedetomidine is incompatible with amphotericin B, diazepam, pantoprazole, and blood or plasma products."
Sources:
Plumb's. Vers. 2021.9.3. Educational Concepts, LLC. Google Play, https://play.google.com/store/apps/details?id=com.plumbs.app.
Plumb's. Vers. 2021.9.3. Educational Concepts, LLC. Google Play, https://play.google.com/store/apps/details?id=com.plumbs.app.